We offer a multi-disciplinary approach to hit-to-lead and lead optimization projects, with the design and synthesis of drug candidates supported by medicinal chemistry, computational chemistry , in-house biology and ADME profiling.

Backed by strong synthetic skills and expert project management, our medicinal chemistry group has an excellent track record of advancing programs, creating solid IP positions and generating preclinical candidates. 

This expertise is supported by a computational chemistry group that offers world-class informatics, molecular modeling and QSAR services that enhance potency, selectivity and pharmacokinetic characteristics of individual molecules and libraries of molecules.

As part of our hit-to-lead/lead optimization services, we offer a kinase profiling service for the discovery and characterization of kinase inhibitors.  This profiling service, offered in collaboration with Carna Biosciences, includes assays for over 150 active protein kinases, representing all major branches of the human kinome.

ADME/PK Laboratory provides advanced capabilities for optimization of ADME and pharmacokinetics through a unique combination of technology and know-how.  The ADME/PK group works closely with medicinal chemists to efficiently engineer desired properties (for example, oral bioavailability, suitable duration of action) into compounds from initial hits through to drug candidates.