Galapagos NV (Euronext & LSE: GLPG) and The ALS Association, a non-profit health organization dedicated to finding a cure for amyotrophic lateral sclerosis (ALS), announced today a new two-year target discovery alliance. Galapagos’ service division BioFocus DPI will apply its adenoviral platform to identify drug targets for the development of new ALS therapies. Under the terms of the agreement, Galapagos may receive up to €2.4 million ($3 million) from The ALS Association. In addition, Galapagos has the option to further develop certain targets identified in the program.

Galapagos NV (Euronext & London AIM: GLPG), an integrated drug discovery company, and UK-based Inpharmatica Ltd. today announced that they have entered into a definitive agreement under which Galapagos will acquire Inpharmatica in an all-share transaction. The acquisition price of Inpharmatica is in three components: the ongoing business is valued at €6.5 million, the estimated cash at an additional €6 million (of which half is due by 31 December 2006), and the potential

Galapagos NV (Euronext & LSE: GLPG) has secured a European Union grant of €500,000 for service division BioFocus DPI’s participation in PROLIGEN, a research consortium focused on enhancing regeneration of injured kidneys. The PROLIGEN consortium, comprising a number of European companies and universities, aims to improve the regenerative capacity of injured kidneys, using information derived from genomics, proteomics, and functional genomics.

Galapagos NV (Euronext & LSE: GLPG) announced today the extension of the target discovery alliance between its service division BioFocus DPI and Cystic Fibrosis Foundation Therapeutics, Inc. (CFFT), the drug discovery and development affiliate of the Cystic Fibrosis Foundation. This 15-month extension exceeds €800,000 in research fees and builds further on the alliance initiated in April 2005.

Galapagos NV (Euronext & LSE: GLPG) announces a first collaboration with privately-held LEO Pharma, a leader in dermatology treatments and critical care. BioFocus DPI, Galapagos’ service division, will use a subset of its natural compound collection for high throughput screening, hit verification, and profiling of selected compounds for LEO Pharma’s antibacterial research program. In return, Galapagos stands to receive up to €400,000 in project fees and up to €3 million in milestone payments. Galapagos may also receive royalties on sales of commercial products resulting from the collaboration

Inpharmatica Ltd. announced today that Schering AG, Germany (FSE:SCH; NYSE:SHR) has commissioned Inpharmatica to develop a target-family specific knowledge-base. The chemogenomics knowledge base, Inpharmatica’s Kinase SARfari™, covers the biology and chemistry of the major group of highly successful targets in drug discovery. Kinase SARfari will be used by Schering as part of its drug discovery process in the field of protein kinases.

Galapagos NV (Euronext & LSE: GLPG) announced today that its service division BioFocus DPI has entered into a drug discovery collaboration with the Institute for OneWorld Health, a non-profit pharmaceutical company headquartered in San Francisco, California. OneWorld Health is working on a number of drug development initiatives for neglected diseases, with support from the Bill & Melinda Gates Foundation and other donors. The collaboration focuses on the development of new drugs to combat diarrheal diseases, a fundamental threat to the health of children in the developing world. Under the terms of the agreement, BioFocus DPI will apply its medicinal chemistry expertise to identify new drug candidates for OneWorld Health’s diarrheal disease program. Total contract value for Galapagos exceeds €3 million over two and a half years.

Galapagos NV (Euronext & LSE: GLPG), an integrated drug discovery company, announced today that its service division BioFocus DPI has entered a new drug discovery collaboration with AstraZeneca (LSE, NYSE, OMX: AZN), a global pharmaceutical leader. This collaboration marks the first time AstraZeneca has selected BioFocus DPI to provide drug discovery services. Under the terms of the agreement, BioFocus DPI will perform hit-to-lead medicinal chemistry services for AstraZeneca’s respiratory and inflammatory drug discovery programs. Total contract value for Galapagos is €650,000.

Galapagos NV (Euronext & LSE: GLPG), an integrated drug discovery company, and Cellzome Inc. have announced that they are collaborating in kinase drug discovery. Under the terms of the agreement, Galapagos’ service division BioFocus DPI gives Cellzome access to its SoftFocus® kinase libraries and provides biological screening and chemistry expertise to find inhibitors of Cellzome’s kinase targets. In this service contract, BioFocus DPI receives an upfront payment for the library access as well as research fees.

Galapagos NV (Euronext & LSE: GLPG), an integrated drug discovery company, announced today closure on the acquisition of all the drug discovery operations of Discovery Partners International (DPI) for €4.25 million in cash. With this, the acquired assets of DPI have now become an integral part of Galapagos’ service division BioFocus DPI.

Galapagos NV (Euronext & LSE: GLPG), a genomics-based drug discovery company, announced today that its service division BioFocus DPI has signed collaborations with Indus Biosciences, a subsidiary of CiVentiChem LLC in Hyderabad, and ProCitius, a division of Sanmar Speciality Chemicals Limited in Chennai, both providers of integrated chemistry services to life sciences companies. Both companies will carry out chemistry services for the BioFocus DPI Discovery Products division, with an option to provide support for client projects conducted by the BioFocus DPI Medicinal Chemistry division.

Galapagos NV (Euronext & LSE: GLPG) announced today that its service division BioFocus has signed an exclusive marketing & sales agreement with Upstate, a wholly-owned subsidiary of Serologicals Corporation (NASDAQ: SERO), for Galapagos’ adenovirus products worldwide, excluding Japan. Under the terms of the agreement, Upstate, a leader in cell signaling products and services for the drug discovery industry, will put its manufacturing, marketing, sales, customer support and technical assistance organization behind promotion of Galapagos’ adenovirus products. In return, Galapagos will receive double-digit royalties on net sales achieved by Upstate.

Galapagos NV (Euronext & LSE: GLPG) announced today that its service division BioFocus has entered into a three-year target discovery alliance with Arthrogen BV, a joint venture of the Dubai Bone & Joint Center and the Academic Medical Center in Amsterdam. The alliance focuses on identifying novel targets for gene therapy applications in rheumatoid arthritis. Under the terms of the agreement, BioFocus will extend its SilenceSelect® collection with new gene sets, set up cellular assays and screen the expanded SilenceSelect collection in the assays. The human protein targets identified in the screens will then be characterized and validated.

Galapagos NV (Euronext & LSE: GLPG), a genomics-based drug discovery company, announced today that Galapagos’ service division, BioFocus, has entered into a three-year collaboration with Roche. This new agreement builds on the successful working history between Roche and BioFocus. Under the terms of the agreement, BioFocus will supply Roche with exclusive chemical compound libraries. Financial terms were not disclosed.

Galapagos NV (Euronext & LSE: GLPG) announced today that it has extended three research collaborations into 2006 with BASF Aktiengesellschaft (NYSE & XET: BASF) in Ludwigshafen, Germany. These extensions will further progress discovery research services for BASF programmes successfully undertaken by Galapagos’ service division BioFocus in 2005. Across the various programmes, BioFocus will offer biology, synthetic and computational chemistry services, plus access to its biologically-targeted SoftFocus® Kinase and GPCR compound libraries against further BASF targets. Under the terms of the extension agreements, BASF will pay compound supply and access fees and will fund research activities. Total contract value of the extensions announced today will exceed € 700,000.

Galapagos NV (Euronext & LSE: GLPG) and Cancer Research Technology (“CRT”), specialists in oncology drug discovery and commercialization, a wholly owned company of Cancer Research UK, announced today that they have entered into a new collaboration in anti-cancer drug discovery research. Under the terms of the agreement Galapagos’ service division BioFocus will perform medicinal chemistry services on a series of CRT anti-cancer drug programs. In return, CRT will fund the work of four BioFocus scientists throughout 2006.

BioFocus, the service division of Galapagos (Euronext & LSE: GLPG), announced today a new three year collaboration in the field of autoimmune discovery research. Under the terms of the agreement, BioFocus will expand its SilenceSelect® si-RNA based gene collection with an additional gene set, develop a dedicated cellular assay in the field of autoimmune disease, and use this assay to run a target discovery screen. Further to the collaboration agreement, Galapagos will receive upfront fees and research and development funding and may receive milestone fees when certain drug discovery criteria are met. Should all criteria on a target be achieved, total potential contract value for Galapagos may exceed € 2 million.

Galapagos announced today that Dr. Angus MacLeod has joined Galapagos’ service division BioFocus as Director of Medicinal Chemistry. Dr. MacLeod was previously with Merck Sharp & Dohme where he spent 21 years in medicinal chemistry, most recently as Senior Director, Medicinal Chemistry. Dr. MacLeod has one of the most impressive track records in the industry contributing to a number of programs leading to clinical candidates, including the Substance P antagonist program that resulted in the marketed product aprepitant (Emend®), and a GABA receptor modulator program. Dr. MacLeod is author/inventor on more than 100 publications and patents.