Ono Pharmaceutical Co., Ltd. (Osaka, Japan) and BioFocus (Saffron Walden, UK) announced today that they have signed a collaboration agreement, focused on discovering novel targets in the field of autoimmune disease. Under the agreement, BioFocus will receive research funding and success payments based on the progress of the collaboration. BioFocus will utilize its unique SilenceSelect target discovery platform to deliver validated targets for Ono’s immunology programs. Ono aims to find modulators for these targets and generate novel and innovative drug candidates.

"We are delighted to enter into this target discovery collaboration with Ono,” said Dr Chris Newton, SVP Galapagos Services and Managing Director BioFocus. “This agreement again demonstrates our unique position in the target discovery arena to produce valuable additions to our clients’ early discovery pipeline”.

Kazuhito Kawabata, Ph.D., Managing Director, Research Headquarters at Ono commented: “We highly appreciate BioFocus’ target discovery platform. We believe this collaboration will lead to the identification of novel drug targets, that will form the basis to generate unique and innovative drugs in the field of autoimmune disease, an area with significant unmet medical needs.”

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About Ono

In keeping with its philosophy of “Dedicated to Man’s Fight against Disease and Pain,” Ono has always striven to achieve its goal of serving as an R&D-oriented global specialty pharmaceuticals, aiming to develop innovative and globally recognized drugs. To do this, Ono has been engaged in drug discovery research based on accumulated technologies and know-how – in areas where its strengths can be fully exploited (i.e. bioactive lipid agonists and enzyme inhibitors such as proteases and kinases). In addition, modulators of membrane transport systems such as ion-channels and transporters as well as biotechnology-based medicines are also the areas of our focus where we drive forward our research effectively deploying our know-how from neuroscience research and our gene assets together with the latest information acquired from global research institutions on drug discovery targets and the cutting-edge drug discovery technologies that biopharmaceutical companies can offer. For more information, visit www.ono.co.jp.

About BioFocus

BioFocus aims to expand its partners’ drug pipelines by accelerating the gene-to-drug candidate discovery process. This is achieved through a comprehensive discovery platform, which includes target discovery in human primary cells, focused as well as diverse compound libraries, in vitro and cell-based screening, structural biology, medicinal chemistry, ADME/PK services, supported by unique chemogenomic and informatics tools. As a service division of Galapagos, BioFocus has over 250 employees based in the UK, the US and Switzerland.

SilenceSelect^®

SilenceSelect is platform technology which utilizes human primary cell assays with ribonucleic acid (RNA) interference (RNAi) through proprietary adenoviral technology to find novel targets. RNAi is a technology that controls the activity of specific genes by introducing small double-stranded RNA fragments into cells. Protein expression from a specific gene is suppressed by the introduction of these artificial RNAs which allows complex functional studies on the protein's role in a specific disease pathway to be performed. BioFocus employs the unique properties of adenoviruses to apply RNAi in human primary cells.

Contact:

Ono Pharmaceutical Co., Ltd  Corporate Communications, Tel +81-6-6263-5670

BioFocus.  Dr Chris Newton, SVP Galapagos Services and Managing Director, BioFocus, Tel: +44 1799 533 500