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ADME / PK
We provide a comprehensive range of in vitro ADME, PK and bioanalytical services. Our flexible approach to your requirements plus our extensive experience ensures the rapid delivery of high quality data you can trust.
Click here for further information on our offering or contact us to receive a quotation.
The following is a list of our validated, SOP-controlled in vitro ADME assays.
| Physicochemical properties |
Metabolic stability |
Drug-drug interactions |
- Kinetic solubility
- Thermodynamic solubility
- Lipophilicity
- Chemical stability
|
- Microsomes
- S9 fraction
- Cryopreserved hepatocytes
- P450 isoforms
- UGT isoforms
- Plasma
- Blood
|
- CYP450 inhibition: fluorescence based
- CYP450 inhibition: mass spectrometry based
- Time dependent CYP450 inhibition
- CYP450 induction
|
| Detailed metabolic studies |
Distribution |
Toxicity |
- Metabolite identification
- Reaction phenotyping
- P450 spectral binding
- Reaction kinetics (Vmax, Km)
|
- Plasma protein binding
- Blood partitioning
- Caco-2 permeation studies
- MDR1-MDCK effective efflux
- P-gp ATPase
- Permeation studies
- Brain tissue binding
|
|
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