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ADME / PK

We provide a comprehensive range of in vitro ADME, PK and bioanalytical services. Our flexible approach to your requirements plus our extensive experience ensures the rapid delivery of high quality data you can trust.

Click here for further information on our offering or contact us to receive a quotation.

The following is a list of our validated, SOP-controlled in vitro ADME assays.

Physicochemical properties	Metabolic stability	Drug-drug interactions
Kinetic solubility Thermodynamic solubility Lipophilicity Chemical stability	Microsomes S9 fraction Cryopreserved hepatocytes P450 isoforms UGT isoforms Plasma Blood	CYP450 inhibition: fluorescence based CYP450 inhibition: mass spectrometry based Time dependent CYP450 inhibition CYP450 induction
Detailed metabolic studies	Distribution	Toxicity
Metabolite identification Reaction phenotyping P450 spectral binding Reaction kinetics (V_max, K_m)	Plasma protein binding Blood partitioning Caco-2 permeation studies MDR1-MDCK effective efflux P-gp ATPase Permeation studies Brain tissue binding	Cytotoxicity

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