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A decade of success
For the past 10 years, BioFocus has pioneered the field of rationally designed focused libraries through our SoftFocus brand. Our novel libraries, designed to target specific gene families, have proved immensely valuable to clients, generating potent and selective molecules at higher rates than other collections. This success has been shown through client publications and clinical candidates directly derived from compounds within the SoftFocus range – providing a level of success we are very proud of.
Client feedback and publications
“Novelty and highly focused design were the deciding factors in Galapagos screening BioFocus’ SoftFocus compounds. We were able to develop a hit series from the initial screen and nominate a pre-clinical candidate in a three year timeline”, Graham Dixon, SVP Drug Discovery, Galapagos.
Oyarzabal et al. Discovery of Mitogen-Activated Protein Kinase-Interacting Kinase 1 Inhibitors by a Comprehensive Fragment-Orientated Virtual Screening Approach. J. Med. Chem., 2010, 53 (18), pp 6618–6628.
Doudou et al,. Inhibitors of PIM-1 Kinase: A Computational Analysis of the Binding Free Energies of a Range of Imidazo [1,2-b] Pyridazines. J. Chem. Inf. Model., 2010, 50 (3), pp 368–379.
Simard et al. High-Throughput Screening To Identify Inhibitors Which Stabilize Inactive Kinase Conformations in p38α. J. Am. Chem. Soc., 2009, 131 (51), pp 18478–18488.
Niculescu-Duvaz et al. Novel Inhibitors of the v-raf Murine Sarcoma Viral Oncogene Homologue B1 (BRAF) Based on a 2,6-Disubstituted Pyrazine Scaffold. J. Med. Chem., 2008, 51 (11), pp 3261–3274.
Sprous et al., Kinase inhibitor recognition by use of a multivariable QSAR model. Journal of Molecular Graphics & Modelling (2006), 24(4).
Bullock et al. Structural Basis of Inhibitor Specificity of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM-1) Kinase. J. Med. Chem., 2005, 48 (24), pp 7604–7614.
Baurin et al, Drug-like Annotation and Duplicate Analysis of a 23-Supplier Chemical Database Totalling 2.7 Million Compounds. J. Chem. Inf. Comput. Sci., 2004, 44 (2), pp 643–651.
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