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GPCR
Our G protein-coupled receptor (GPCR) libraries have been designed using Thematic Analysis, our proprietary system for analyzing GPCR receptors and their interactions with ligands. We have developed two types of libraries: SoftFocus GPCR, drug-like molecules; and ThemePair GPCR, lower molecular weight, lower cLogP compounds.
GPCRs are cell membrane proteins widely found in many organ systems. They form an important part of drug development as one of the most heavily investigated targets for action.
Please contact us for more information, or download datasheets and stock files from our secure website.
SoftFocus GPCR
The SoftFocus libraries are based around central cores selected to target specific sub-sets of GPCRs. Each core contains two or more points of diversity where specific monomer combinations, chosen using Thematic Analysis, are included.
Each individual library has been selected to target specific sub-sets of GPCRs including family A and family B. SoftFocus GPCR libraries provide selective hits across a range of these receptors and have a track record of delivering:
- Antagonist hit series against a range of aminergic, peptidic, purinergic and lipid targets
- Agonist hit series against several peptidic targets
- Agonist and antagonist hit series against orphan and recently de-orphanized receptors
Download more information about SoftFocus GPCR
ThemePair GPCR
The libraries consist of low molecular weight, low cLogP compounds. In a similar way to the SoftFocus GPCR libraries, ThemePair libraries are built around a set of central cores with a range of different substituents. The libraries cover the majority of GPCR targets and are likely to provide agonists, antagonists, and allosteric modulators.
Download more information about ThemePair GPCR
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