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Protease
We have developed a novel approach to protease-focused library design. Detailed analysis of more than fifty protease ligand complexes from the Protein Data Bank has allowed us to expand on the work of Fairlie1 to develop a protease template, suitable for the design of compound libraries targeted towards serine and cysteine proteases.
Proteases are involved in a multitude of physiological reactions from simple digestion of food proteins to highly-regulated cascades. Proteases are known to be inhibited by other small protease molecules making them ideal candidates for pharmaceutical research.
Please contact us for more information, or visit eMolecules to see a list of current stock.
1. D. P. Fairlie et al., J. Med. Chem. 2000, 43, 1271-1281.
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