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Hit identification
Verification of active compounds identified through high throughput screening is an important part of the drug discovery process. Through a rigorous evaluation of potential hits we select the most promising compounds to progress to lead generation programs.
This process includes:
- Exclusion of hits with potential reactivity or assay interference
- Re-synthesis and confirmation of structure
- Re-testing and confirmation of on-target activity
- Assessment of drug-like properties using computational analysis and early physicochemical and ADME measurements
- Assessment of patent potential
- Structure-activity relationship (SAR) evaluation
- Ranking of hits or hit series to select the most promising for the hit-to-lead phase
Our staff have experience of evaluating numerous early stage programs and identifying potential pitfalls, and can direct strategy for successful progression to hit-to-lead studies.
If you’d like to know more about our services, discuss custom assays, specific research, or get a quote, please contact us.
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