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Lead optimization

We have a wealth of experience in lead optimization, delivering compounds that meet project-specific molecular target profiles. We develop fully characterized, high quality candidate drugs, with data supporting progression into investigational new drug studies.

Our outputs include:

  • Candidates with maximised potency and selectivity, and minimised toxicity
  • Demonstrable pharmacokinetics
  • Ranking of lead compounds against project criteria
  • Patent filings
  • Selection of a pre-clinical candidate meeting agreed criteria

Together with our assay development and screening, in silico drug discovery and ADME/PK groups, we operate in highly efficient project teams, rapidly progressing to key decision points. We also have many years of experience providing medicinal chemistry services in joint project teams with a variety of pharma and biotech companies.

If you’d like to know more about our services, discuss specific projects, or get a quote, please contact us.





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BioFocus®, SoftFocus®, Galapagos®, SilenceSelect® and FLeXSelect® ThemePair™, FieldFocus™, HDRA™. Helical Domain Recognition Analysis™, 2D Roadmap™, Thematic Analysis™, SFK™, SFI™, SFG™ and PrimePath™ are trademarks of Galapagos NV and/or its affiliates.