Structural biology

Our structural biology platform supports structure-based drug discovery from determination of novel targets through to final structures – including incorporation of your selected ligands. We employ the latest techniques, equipment and have expertise in high-throughput gene expression, automated protein purification and crystallization, and X-ray crystallography.

We work with novel targets, or examples from the Protein Database (PDB), as well as our in-house library, Crystal Bank.

Our structural biology services can be offered as part of an integrated drug discovery program or in support of your own lead optimization or fragment based discovery programs.

If you would like to know more about our services discuss specific research, or get a quote, please contact us.

In this section:

• Protein production and crystallization: cloning, expression, purification and crystallization of target proteins
• X-ray crystallography: data collection and structure solution
• Fragment screening: using libraries designed with proprietary chemogenomics tools to identify fragment leads for medicinal chemistry
• Crystal Bank: a collection of proteins for rapid X-ray structure determination in the presence of client ligands

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