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Fragment screening
Our platform offers several options for the identification of fragments to be used in X-ray crystallography studies. This choice is determined by the target of interest. Our experienced scientists are on hand to offer advice in planning fragment screening programs.
All results are subjected to intensive quality control before being released to you or passed on to our medicinal chemistry teams in order to optimize drug-like properties and to deliver pre-clinical candidates.
Screening techniques
- High concentration biochemical screening builds on our experience in assay development and screening. We develop assays for a wide range of enzyme targets, using our carefully selected proprietary fragment libraries
- Biophysical methods, such as target immobilized NMR give direct fragment-based data when enzymatic information isn’t available - or desired. Combining biochemical screening with direct binding methods can offer increased hit validation
- X-ray crystallography can then be used to determine structures using fragment ligands shown to bind to the target. Fragments are bound to target active sites using crystal soaking or co-crystallization and high-throughput X-ray crystallography is used to determine structures.
If you would like to know more about our services, discuss custom assays, specific research, or get a quote, please contact us.
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